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API & excipient characterisation
Processing of drug substance and excipients can have a significant effect on surface properties & subsequent stability/bioavailability of the active. To clarify your formulation options full understanding of bulk and surface physicochemical properties is required.
Enabling technologies allow empirical observations such as batch to batch variation, cohesive tendency and powder flow to be correlated to actual physicochemical properties. Our experience and range of solid state characterisation capabilities are used to compare bulk and surface properties of drug substance, excipients, granules and aggregates providing you with a detailed physicochemical profile.
Types of analysis include:
• Particle size and shape distribution
• Surface morphology/roughness at µm &
nm scale
• Chemical and material mapping down to
nm scale
• Crystal properties, polymorphs/hydrates/salts
• Bulk versus surface physicochemical properties
• Surface amorphous/polymorphic state
• Cohesive/adhesive/mechanical properties |
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