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controlled release
Solid dosage design can obtain further levels of complexity, through the inclusion of polymer coatings and matrix systems to control the rate of drug delivery or the site of release.
Our combination of high resolution imaging and chemical spectroscopy techniques can rapidly assist in the development and protection of optimised processing parameters. We can accurately assess film coating integrity on a single pellet through to providing greater insight into the complex interplay of polymer structure on the physicochemical nature of the active.
Types of analysis include:
• Chemical identification of components
• Spatial mapping & quantification of components
• Film coating integrity & thickness determination
• Identification of component migration / segregation & contamination
• In-situ identification of drug form within polymer matrices
• Identification of polymer & drug degradation
• In-vitro assessment of drug release mechanisms
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