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selected publications
The following is a list of selected publications of Molecular Profiles Ltd and the Laboratory of Biophysics and Surface Analysis, University of Nottingham, the founding institution of Molecular Profiles. Re-prints of any article in the three sections can be ordered using the check box by the appropriate article.
   
 
> pharmaceuticals
> polymers
> biopharmaceuticals
       
 pharmaceuticals

Differential scanning calorimetry & scanning thermal microscopy analysis of pharmaceutical materials Bond L, Allen S, Davies MC, Roberts CJ, Shivji AP, Tendler SJB,.Williams PM, Zhang J. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2002, Vol 243, Iss 1-2, pp 71-82.

An in situ dissolution study of aspirin crystal planes (100) and (001) by atomic force microscopy Danesh A, Connell SD, Davies MC, Tendler SJB, Roberts CJ, Williams PM, Wilkins MJ PHARMACEUTICAL RESEARCH, 2001 Vol. 18, pp. 299-303.

Polymorphic discrimination using atomic force microscopy: Distinguishing between two polymorphs of t Danesh A, Chen X, Davies MC, Roberts CJ, Sanders GHW, Tendler SJB, Williams PM, Wilkins MJ LANGMUIR, 2000, Vol. 16, pp. 866-870.

Discrimination of polymorphic forms of a drug product by localized thermal analysis Sanders GHW, Roberts CJ, Danesh A, Murray AJ, Price DM, Davies MC, Tendler SJB, Wilkins MJ JOURNAL OF MICROSCOPY-OXFORD 2000, Vol. 198, pp. 77-81.

Identification of the alternate faces of a single aspirin crystal using AFM Danesh A, Davies MC, Hinder S, Roberts CJ, Tendler SJB, Williams PM, Wilkins MJ ANAL. CHEM., 2000, Vol. 72, pp. 3419-3422.

Polymorphic discrimination using atomic force microscopy:-distinguishing between two single crystal Danesh A, Chen X, Davies MC, Roberts CJ, Sanders GHW, Tendler SJB, Williams PM, Wilkins MJ PHARMACEUTICAL RESEARCH, 2000, Vol. 17, pp. 887-890.

TOF-SIMS characterization and imaging of controlled-release drug delivery systems Belu AM, Davies MC, Newton JM, Patel N ANAL. CHEM., 2000, Vol. 72, pp. 5625-5638.

Characterisation of delivery systems, XPS, SIMS and AFM analysis Davies MC, Shakesheff KM, Roberts CJ, Tendler SJB, Patel N, Bryan S ENCYCLOPEDIA OF CONTROLLED DRUG DELIVERY, 1999, Wiley, New York, pp. 269-275.

The use of SIMS, XPS and in situ AFM to probe the acid catalysed hydrolysis of poly(orthoesters) Leadley SR, Shakesheff KM, Davies MC, Heller J, Franson NM, Paul AJ, Brown AM, Watts JF BIOMATERIALS, 1998, Vol. 19, pp. 1353-1360

Chemical Imaging of Pharmaceuticals by Time-of-Flight Secondary Ion Mass Spectrometry. Luk, S.Y.; Patel, N.; Davies, M.C. SPECTROSCOPY EUROPE, 2003, 15/1, pp 8-12

Investigating the interfacial properties of single-liquid nanodroplets by atomic force microscopy Connell SDA, Allen s, Roberts CJ, Davies J, Davies MC, Tendler SJB, Williams PM LANGMUIR, 2002, Vol. 18, pp. 1719-1728.

Detection and determination of surface levels of poloxamer and PVA surfactant on biodegradable nanos Scholes PD, Coombes AGA, Illum L, Davis SS, Watts JF, Ustariz C, Vert M, Davies MC JOURNAL OF CONTROLLED RELEASE, 1999, Vol. 59, pp. 261-278.

Screening the biointeractions of nanospheres intended for site-specific delivery using SPR McGurk SL, Davies MC, Roberts CJ, Tendler SJB, Williams PM JOURNAL OF COLLOIDS AND INTERFACE SCIENCE, 1999, Vol. 218, pp. 456-461.

A study of single drug particle adhesion interactions using atomic force microscopy Eve JK, Patel N, Luk SY, Ebbens SJ, Roberts CJ INTERNATIONAL JOURNAL OF PHARMACEUTICS 2002, Vol. 238, pp. 17-27.

Identifying and mapping surface amorphous domains Ward S, Perkins M, Zhang J, Roberts CJ, Madden CE, Luk SY, Patel N, Ebbens SJ; PHARMACEUTICAL RESEARCH, 2005, Vol. 22, pp. 1195-1202

Determination of the surface free energy of crystalline and amorphous lactose by atomic force microscopy adhesion measurement Zhang J, Ebbens S, Chen X, Jin Z, Luk SY, Madden CE, Patel N, Roberts CJ; PHARMACEUTICAL RESEARCH, 2006, Vol. 32, pp.401-407

Fakes in the Firing Line Farnsworth S, Madden CE, Parker A; European Pharmaceutical Executive, 2006, Issue 1, pp37

Characterization of Antigens Adsorbed to Anionic PLG Microparticles by XPS and TOF-SIMS Chesko J, Kazzaz J, Ugozzoli M, Singh M, O'Hagan DT, Madden C, Perkins M, Patel N, JOURNAL OF PHARMACEUTICAL SCIENCES, 2008, Vol 97, Iss 4, pp 1443-1453.

 polymers

The role of SPM in drug delivery research Shakesheff KM, Davies MC, Roberts CJ, Tendler SJB, Williams PM CRITICAL REVIEWS IN THERAPEUTIC DRUG CARRIER SYSTEMS, 1996, Vol. 59, pp. 131-32

The degradation of a thin polymer film studied by simultaneous in situ atomic force microscopy and s Chen X, Shakesheff KM, Davies MC, Heller J, Roberts CJ, Tendler SJB, Williams PM JOURNAL OF PHYSICAL CHEMISTRY, 1995, Vol. 99 pp. 11537-11542

Mapping the surface characteristics of polystyrene microtiter wells by a multi-mode scanning force m Allen S, Connell SD, Davies MC, Tendler SJB, Roberts CJ, Williams PM J. COLL. INTERF. SCI., 2001, Vol. 242, pp. 470-476.

Atomic force microscope and surface plasmon resonance investigation of polymer blends of poly([2-(me Clarke S, Davies MC, Tendler SJB, Roberts CJ, Williams PM, Lewis AL, O'Byrne V MACROMOLECULES, 2001, Vol. 34, pp. 4166-4172.

Surface mobility of 2-methacryloyloxyethyl phosphorylcholine-co-lauryl methacrylate polymers Clarke S, Davies MC, Roberts CJ, Tendler SJB, Williams PM, O'Byrne V, Lewis AL, Russell J LANGMUIR, 2000, Vol. 16, pp. 5116-5122.

Chemical and morphological analysis of surface enrichment in a biodegradable polymer blend by phase- Chen X, McGurk SL, Davies MC, Roberts CJ, Shakesheff KM, Tendler SJB, Williams PM, Davies J, Dawkes AC, Domb A MACROMOLECULES, 1998, Vol. 31, pp. 2278-2283.

Analysis of the surface chemical structure of copolymers of poly(sebacic anhydride) with ricinoleic Leadley SR, Davies MC, Domb A, Nudelman R, Paul AJ, Beamson G MACROMOLECULES, 1998, Vol. 31, pp. 8957-8965.

Surface analysis of biodegradable polymer blends poly(sebacic anhydride) and poly(lactic acid) Davies MC, Shakesheff KM, Shard AG, Domb A, Roberts CJ, Tendler SJB, Williams PM MACROMOLECULES, 1996, Vol. 29, pp. 2205-2212.

Micro- and macrothermal analysis of a bioactive surface-engineered polymer formed by physical entrap Zhang J, Roberts CJ, Shakesheff KM, Davies MC, Tendler SJB. MACROMOLECULES 2003, Vol.36, pp.1215-1221.

Preparation of a poly(methyl methacrylate)/ultrahigh molecular weight polyethylene blend using super Zhang JX, Busby AJ, Roberts CJ, Chen XY, Davies MC, Tendler SJB, Howdle SM. MACROMOLECULES 2002, Vol.35, pp.8869-8877.

 biopharmaceuticals

Exploring protein structure and function using atomic force microscopy Woodward IS, Ebbens SJ, Roberts CJ, Tendler SJB. INDUSTRIAL PROTEINS, 2002, Issue 10, No. 2, pp. 11-13

Atomic force microscopy of cationic liposomes Thompson NH, Collin I, Davies MC, Palin K, Parkins D, Roberts CJ, Tendler SJB, Williams PM LANGMUIR, 2000, Vol. 16, pp. 4813-4818.

In-situ atomic force microscopy study of beta-amyloid fibrillization Blackley HKL, Sanders GHW, Davies MC, Roberts CJ, Tendler SJB, Wilkinson MJ JOURNAL OF MOLECULAR BIOLOGY, 2000, Vol. 298, pp. 833-840

Atomic force microscopy studies of intercalation-induced changes in plasmid DNA tertiary structure Pope LH, Davies MC, Laughton CA, Roberts CJ, Tendler SJB, Williams PM JOURNAL OF MICROSCOPY-OXFORD, 2000, Vol. 199, pp. 68-78.

Characterization of the surfaces generated by liposome binding to the modified dextran matrix of a s Erb EM, Chen XY, Allen S, Roberts CJ, Tendler SJB, Davies MC, Forsen S ANALYTICAL BIOCHEMISTRY, 2000, Vol. 280, pp. 29-35.

Probing protein-peptide-protein molecular architecture by atomic force microscopy and surface plasmo Stevens MM, Allen S, Chan WC, Davies MC, Roberts CJ, Tendler SJB, Williams PM ANALYST, 2000, Vol. 125, pp. 245-250.

Interaction-induced changes in DNA supercoiling observed in real time by atomic force microscopy Pope LH, Davies MC, Laughton CA, Roberts CJ, Tendler SJB, Williams PM ANALYTICA CHEMICA ACTA, 1999, Vol. 400, pp. 27-32.

DNA analysis with scanning probe microscopy Pope LH, Davies MC, Roberts CJ, Tendler SJB, Williams PM ANALYTICAL COMMUNICATIONS, 1998, Vol. 35, pp. H5-H7.

Hidden complexity in the mechanical properties of titin Williams, PM, Fowler, SB, Best, RB, Toca-Herrera, JL, Scott, KA, Steward, A, Clarke, J. NATURE, 2003 Vol.422, pp.446-449.

Polyethylenimine-graft-poly(ethylene glycol) copolymers: Influence of copolymer block structure on D Petersen H, Fechner PM, Martin AL, Kunath K, Stolnik S, Roberts CJ, Fischer D, Davies MC, Kissel T. BIOCONJUGATE CHEMISTRY 2002, Vol.13, pp.845-854.

Star-shaped poly(ethylene glycol)-block-polyethylenimine copolymers enhance DNA condensation of low Petersen H, Kunath K, Martin AL, Stolnik S, Roberts CJ, Davies MC, Kissel T. BIOMACROMOLECULES 2002, Vol.3, pp.926-936.

Discriminating single molecule DNA binding modes by single molecule force spectroscopy Krautbauer R, Pope LH, Schrader TE, Allen S, Gaub HE FEBS Letters, 2002, Vol. 510, pp. 154-158.

Force sensing and mapping by atomic force microscopy Green NH, Allen S, Davies MC, Roberts CJ, Tendler SJB, Williams PM. TRAC-TRENDS IN ANALYTICAL CHEMISTRY, 2002, Vol. 21, pp. 64-73.

Probing DNA Duplex Formation and DNA-Drug Interactions by the Quartz Crystal Microbalance Technique Pope LH, Allen S, Davies MC, Roberts CJ, Tendler SJB, Williams PM LANGMUIR, 2001, Vol. 17, pp. 8300-8304.

Surface plasmon resonance analysis of dynamic biological interactions with biomaterials Green RJ, Frazier RA, Shakesheff KM, Davies MC, Roberts CJ, Tendler SJB, BIOMATERIALS, 2000, Vol. 21, pp. 1823-1835.

Observation of DNA-Polymer condensate formation in real-time at the molecular level Martin A, Stolnik S, Davies MC, Laughton CA, Roberts CJ, Tendler SJB, Williams PM FEBS LETTERS, 2000, Vol. 480, pp. 106-112.

Direct measurement of protein adhesion at biomaterial surfaces by scanning force microscopy Vansteenkiste SO, Corneillie SI, Schacht EH, Chen X, Davies MC, Moens M, Van Vaeck L LANGMUIR, 2000, Vol. 16, pp. 3330-3336

Application of protein-coated scanning force microscopy probes in measurements of surface affinity t Chen X, Patel N, Davies MC, Roberts CJ, Tendler SJB, Williams PM, Davies J, Dawkes AC, Edwards JC APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING, 1998, Vol. 66, pp. S631-S634

The application of force microscopy to immunodiagnostic systems: Imaging and molecular adhesion meas Allen S, Chen X, Davies J, Davies MC, Dawkes AC, Edwards JC, Roberts CJ, Tendler SJB, Williams PM APPL. PHYS. A, 1998, Vol. 66, pp. S255-S261.

Immobilization of protein molecules onto homogenous and mixed carboxylate terminated self assembled Patel N, Davies MC, Hartshorne M, Heaton M, Roberts CJ, Tendler SJB, Williams PM LANGMUIR, 1997, Vol. 13, pp. 6485-6490

Atomic force microscopy in analytical biotechnology Allen S, Davies MC, Roberts CJ, Tendler SJB, Williams PM TRENDS IN BIOTECH., 1997, Vol. 15, pp. 101-105

Electrostatic interactions observed when imaging proteins with the atomic force microscope Rossell JP, Allen S, Davies MC, Roberts CJ, Tendler SJB, Williams PM. ULTRAMICROSCOPY, 2003, Vol.96, pp.37-46

Analytical descriptions of dynamic force spectroscopy: behaviour of multiple connections Philip M. Williams Williams PM. ANALYTICA CHIMICA ACTA 2003, Vol.479, pp.107-115.

Bifunctional atomic force microscopy probes for molecular screening applications Wilde LM, Allen S, Davies MC, Tendler SJB, Williams PM, Roberts CJ. ANALYTICA CHIMICA ACTA 2003, Vol.479, pp.77-85

Direct measurement of drug-enzyme interactions by atomic force microscopy; dihydrofolate reductase a Rigby-Singleton SM, Allen S, Davies MC, Roberts CJ, Tendler SJB, Williams PM. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2 2002, pp.1722-1727.

Discriminating small molecule DNA binding modes by single molecule force spectroscopy Krautbauer R, Pope LH, Schrader TE, Allen S, Gaub HE. FEBS LETTERS 2002, Vol.510, pp.154-158.

Towards nanoscale metrology for biomolecular imaging by atomic force microscopy Abdelhady HG, Allen S, Ebbens SJ, Madden CE, Patel N, Roberts CJ, Zhang J; NANOTECHNOLOGY, 2005, Vol. 16, pp. 966-973

Progressing single biomolecule force spectroscopy measurements for the screening of DNA binding agents Zhang W, Barbagallo R, Madden CE, Roberts CJ, Woolford A, Allen S; NANOTECHNOLOGY, 2005, Vol. 16, pp. 2325-2333